FAQ

  • Aequival® 2′-FL is structurally identical to the 2′-fucosyllactose (2′-FL) component naturally present in human milk. 2′-FL is the most prevalent human milk oligosaccharide (HMO)1.
    Human milk oligosaccharides (HMOs) are non-digestible carbohydrates and are the third most abundant component in human milk after lactose and fat. More than 200 different varieties have currently been identified in human milk2, of which 2’-FL is the most prevalent.
    Research has shown 2’-FL to have a number of important functions, the two most important of which are the bifidogenic effect12-13 and anti-pathogenic effects.8-11 Additional benefits described are reducing the risk of allergy14-15 , anti-inflammatory effects17, affecting brain development18-19, affecting gut maturation and gut barrier function16. Any potential benefit for consumers should not be considered a health claim, but may be used in the development of potential health claims in strict compliance with local legal requirements.
    While much of the evidence for the health benefits of HMOs and specifically for 2’-FL comes from in vitro and in vivo studies, recently, a number of important clinical studies have been conducted, both in infants and adults, showing the first evidence of both good tolerability and potential efficacy of 2’-FL supplementation21-22,25-26. You can find more information here.
  • We have five sales offices which are located in the Netherlands, USA, Brazil, Singapore and China. Please send us a message through our contact page.
  • The first HMO FrieslandCampina DOMO will launch is Aequival® 2’-FL. We will offer 2'-FL in powder form for dry blending. You can find more information on our product here. As there are more than 200 different varieties of HMOs, DOMO is developing a range of HMOs that will be commercially available in the foreseeable future.
    Please see the product data sheet for more information on this.
  • Aequival 2’-FL has been developed as an ingredient for Infant Formula, but also has a wide range of uses in other therapeutic applications.
    Aequival® 2'-FL powder will be packed in 20 kg bags.
  • Suggestions for declaration of Aequival® 2'-FL on the ingredients list include: 2'-fucosyllactose, 2'-fucosyllactose (HMO) or 2'-fucosyllactose powder. The particular declaration used should be checked with the regulatory authorities of the country in question.
    Aequival® 2'-FL is generally safe to use for both children and adults. Aequival® 2'-FL received GRAS status in the USA. GRAS is an acronym for the phrase ‘Generally Recommended As Safe’. By providing this statement the FDA in the US approves that the ingredient has been shown to be safe under conditions of its intended use. Recently, a number of important clinical studies have been conducted, both in infants and adults, showing the first evidence of both good tolerability and potential efficacy of 2’-FL supplementation21-22,25-26. More information can be found here.
    Aequival® 2'-FL can be used as an ingredient in multiple geographical areas, including all member states of the EU (2018). Aequival® 2'-FL received GRAS (Generally Recognised as Safe) approval for use in food and infant food in the USA in 2018. We always recommend that manufacturers check the status of this ingredient for the geographic area in question with the relevant local regulatory authority.
    GRAS is an acronym for the phrase 'Generally Recognised As Safe' for use in foods. Aequival® 2'-FL received GRAS (Generally Recognised as Safe) approval for use infant nutrition and food in the USA in 2018.
    We have the following certificates: FSSC 22000- 2010, GMP+, ISO 14001, OHSAS – ISO 18001.
  • The scientific definition of prebiotics is: non-digestible food ingredients that beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon. Source: Gibson, G.R. and Roberfroid, M.B., “Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of  Prebiotics,” Journal of Nutrition, 125: 1401-1412 (1995).
    Probiotics are the living bacteria, like Bifidobacteria that deliver a health benefit to the host.
    Probiotics are actually the living organisms, like Bifidobacteria. In contrast, a prebiotic ingredient such as 2'-FL or GOS provides food for the growth of these beneficial bacteria, so they can do their job and ultimately help your body help itself by optimizing natural processes.